Drug interactions
Mycophenolate mofetil + Sodium zirconium cyclosilicate
Severity: Minor
Mycophenolate mofetil and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH, and mycophenolate mofetil absorption depends on acidic conditions. Exposure to mycophenolic acid may be reduced.
What this interaction means in plain words
Mycophenolate mofetil and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mycophenolate mofetil belongs to Miscellaneous; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may reduce dissolution and absorption of oral mycophenolate mofetil.
What to do
Give mycophenolate at least 2 hours before or after sodium zirconium cyclosilicate. Monitor for reduced immunosuppressive efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Mycophenolate mofetil with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Mycophenolate mofetil and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can raise gastric pH, and mycophenolate mofetil absorption depends on acidic conditions. Exposure to mycophenolic acid may be reduced.
How serious is the interaction between Mycophenolate mofetil and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mycophenolate at least 2 hours before or after sodium zirconium cyclosilicate. Monitor for reduced immunosuppressive efficacy.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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