Drug interactions
Nabilone + Naltrexone
Severity: Minor
Nabilone and Naltrexone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone blocks opioid receptors, which interact with the endocannabinoid system, and some reports suggest it may modify cannabinoid effects, possibly intensifying them. The clinical significance with nabilone is uncertain.
What this interaction means in plain words
Nabilone and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nabilone belongs to Gastrointestinal Tract; Naltrexone belongs to Musculoskeletal.
Why it happens
Possible pharmacodynamic modulation of cannabinoid effects via opioid receptor antagonism; not well established.
What to do
No dose change is routinely required; monitor for increased cannabinoid effects such as sedation, dizziness or mood change. Reassess if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabilone
Other interactions of Naltrexone
- Naldemedine + Naltrexone Major
- Naloxegol + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
Frequently asked questions
Can I take Nabilone with Naltrexone?
MediHelp rates the interaction as minor. Nabilone and Naltrexone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naltrexone blocks opioid receptors, which interact with the endocannabinoid system, and some reports suggest it may modify cannabinoid effects, possibly intensifying them. The clinical significance with nabilone is uncertain.
How serious is the interaction between Nabilone and Naltrexone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required; monitor for increased cannabinoid effects such as sedation, dizziness or mood change. Reassess if adverse effects emerge.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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