Drug interactions
Nabilone + Prochlorperazine
Severity: Moderate
Nabilone and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabilone causes drowsiness, dizziness and mood changes, and prochlorperazine adds sedation and orthostatic hypotension. Together they may cause increased sedation and impaired judgement.
What this interaction means in plain words
Nabilone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation, dizziness and hypotension, and advise against driving or alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Nabilone
Frequently asked questions
Can I take Nabilone with Prochlorperazine?
MediHelp rates the interaction as moderate. Nabilone and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabilone causes drowsiness, dizziness and mood changes, and prochlorperazine adds sedation and orthostatic hypotension. Together they may cause increased sedation and impaired judgement.
How serious is the interaction between Nabilone and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, dizziness and hypotension, and advise against driving or alcohol use.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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