Drug interactions
Nabilone + Propofol
Severity: Moderate
Nabilone and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent general anesthetic and sedative, and prior or concurrent nabilone can enhance sedation and reduce the dose needed. Cardiorespiratory depression may be more pronounced.
What this interaction means in plain words
Nabilone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nabilone belongs to Gastrointestinal Tract; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Inform the anesthesia team of nabilone use and titrate propofol to effect with standard cardiorespiratory monitoring. Expect a possibly lower dose requirement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Propofol
Frequently asked questions
Can I take Nabilone with Propofol?
MediHelp rates the interaction as moderate. Nabilone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent general anesthetic and sedative, and prior or concurrent nabilone can enhance sedation and reduce the dose needed. Cardiorespiratory depression may be more pronounced.
How serious is the interaction between Nabilone and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of nabilone use and titrate propofol to effect with standard cardiorespiratory monitoring. Expect a possibly lower dose requirement.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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