Drug interactions
Nebivolol + Rolapitant
Severity: Moderate
Nebivolol and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is metabolized mainly by CYP2D6, and rolapitant inhibits this enzyme for weeks. Higher nebivolol exposure may cause bradycardia, hypotension and dizziness.
What this interaction means in plain words
Nebivolol and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nebivolol belongs to Cardiovascular; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing nebivolol clearance.
What to do
Monitor heart rate and blood pressure. Reduce the nebivolol dose if symptomatic bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Rolapitant?
MediHelp rates the interaction as moderate. Nebivolol and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is metabolized mainly by CYP2D6, and rolapitant inhibits this enzyme for weeks. Higher nebivolol exposure may cause bradycardia, hypotension and dizziness.
How serious is the interaction between Nebivolol and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure. Reduce the nebivolol dose if symptomatic bradycardia or hypotension develops.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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