Drug interactions
Nebivolol + Silodosin
Severity: Minor
Nebivolol and Silodosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin may cause postural hypotension and dizziness. Nebivolol, which also has vasodilating properties, may add to the blood pressure reduction.
What this interaction means in plain words
Nebivolol and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nebivolol belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 blockade and beta-blockade with nitric oxide-mediated vasodilation.
What to do
Check standing blood pressure when starting or adjusting either drug and advise slow posture changes. Lower the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Nebivolol with Silodosin?
MediHelp rates the interaction as minor. Nebivolol and Silodosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Silodosin may cause postural hypotension and dizziness. Nebivolol, which also has vasodilating properties, may add to the blood pressure reduction.
How serious is the interaction between Nebivolol and Silodosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check standing blood pressure when starting or adjusting either drug and advise slow posture changes. Lower the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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