Drug interactions
Nefopam + Trimipramine
Severity: Moderate
Nefopam and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefopam has anticholinergic and sympathomimetic effects and inhibits monoamine reuptake, so combining it with a tricyclic may add to tachycardia, dry mouth, urinary retention and seizure risk. Labeling advises caution with tricyclics.
What this interaction means in plain words
Nefopam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nefopam belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive anticholinergic and noradrenergic/serotonergic reuptake effects; seizure threshold may be lowered by both.
What to do
Monitor heart rate and for anticholinergic effects and agitation or seizures. Prefer an alternative analgesic in patients with cardiac disease, epilepsy or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Nefopam
- Amitriptyline + Nefopam Moderate
- Clomipramine + Nefopam Moderate
- Desipramine + Nefopam Moderate
- Imipramine + Nefopam Moderate
- Maprotiline + Nefopam Moderate
- Nefopam + Nortriptyline Moderate
Frequently asked questions
Can I take Nefopam with Trimipramine?
MediHelp rates the interaction as moderate. Nefopam and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefopam has anticholinergic and sympathomimetic effects and inhibits monoamine reuptake, so combining it with a tricyclic may add to tachycardia, dry mouth, urinary retention and seizure risk. Labeling advises caution with tricyclics.
How serious is the interaction between Nefopam and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and for anticholinergic effects and agitation or seizures. Prefer an alternative analgesic in patients with cardiac disease, epilepsy or urinary retention.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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