Drug interactions
Nevirapine + Oxycodone
Severity: Moderate
Nevirapine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can reduce oxycodone plasma concentrations, potentially causing inadequate pain relief or withdrawal symptoms. Oxycodone levels may rise after nevirapine is stopped.
What this interaction means in plain words
Nevirapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Oxycodone belongs to Musculoskeletal.
Why it happens
Nevirapine induces CYP3A4, accelerating oxycodone clearance.
What to do
Monitor analgesia and withdrawal signs and titrate oxycodone upward as needed. Reduce the dose and monitor for toxicity if nevirapine is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Nevirapine with Oxycodone?
MediHelp rates the interaction as moderate. Nevirapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and can reduce oxycodone plasma concentrations, potentially causing inadequate pain relief or withdrawal symptoms. Oxycodone levels may rise after nevirapine is stopped.
How serious is the interaction between Nevirapine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and withdrawal signs and titrate oxycodone upward as needed. Reduce the dose and monitor for toxicity if nevirapine is discontinued.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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