Drug interactions
Nevirapine + Palbociclib
Severity: Moderate
Nevirapine and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower palbociclib exposure through CYP3A induction, possibly reducing efficacy. The size of the effect is uncertain and expected to be smaller than that with strong inducers.
What this interaction means in plain words
Nevirapine and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Palbociclib belongs to Oncology.
Why it happens
Nevirapine induces CYP3A4, accelerating palbociclib metabolism.
What to do
Choose a non-inducing antiretroviral where feasible. If coadministered, monitor tumor response and neutrophil counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Nevirapine with Palbociclib?
MediHelp rates the interaction as moderate. Nevirapine and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower palbociclib exposure through CYP3A induction, possibly reducing efficacy. The size of the effect is uncertain and expected to be smaller than that with strong inducers.
How serious is the interaction between Nevirapine and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-inducing antiretroviral where feasible. If coadministered, monitor tumor response and neutrophil counts.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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