Drug interactions
Nevirapine + Pretomanid
Severity: Major
Nevirapine and Pretomanid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with hepatotoxicity, and nevirapine can also cause serious liver injury. Using them together may increase the risk of liver damage.
What this interaction means in plain words
Nevirapine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nevirapine belongs to Anti Virals; Pretomanid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity from two hepatotoxic drugs.
What to do
Avoid the combination if possible and consider an alternative antiretroviral such as an integrase inhibitor-based regimen. If used, monitor liver enzymes closely and stop for significant elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Nevirapine with Pretomanid?
MediHelp rates the interaction as major. Nevirapine and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pretomanid-containing regimens are associated with hepatotoxicity, and nevirapine can also cause serious liver injury. Using them together may increase the risk of liver damage.
How serious is the interaction between Nevirapine and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and consider an alternative antiretroviral such as an integrase inhibitor-based regimen. If used, monitor liver enzymes closely and stop for significant elevations.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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