Drug interactions
Nevirapine + Ruxolitinib
Severity: Minor
Nevirapine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is a CYP3A4 substrate, and nevirapine as a CYP3A4 inducer would be expected to lower, not raise, its exposure. Reduced ruxolitinib exposure could weaken efficacy, though the effect is likely small.
What this interaction means in plain words
Nevirapine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nevirapine belongs to Anti Virals; Ruxolitinib belongs to Oncology.
Why it happens
Nevirapine induction of CYP3A4 may increase ruxolitinib clearance.
What to do
Monitor spleen size, symptoms and blood counts, and titrate ruxolitinib to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Nevirapine with Ruxolitinib?
MediHelp rates the interaction as minor. Nevirapine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ruxolitinib is a CYP3A4 substrate, and nevirapine as a CYP3A4 inducer would be expected to lower, not raise, its exposure. Reduced ruxolitinib exposure could weaken efficacy, though the effect is likely small.
How serious is the interaction between Nevirapine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen size, symptoms and blood counts, and titrate ruxolitinib to response.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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