Drug interactions
Nevirapine + Temsirolimus
Severity: Moderate
Nevirapine and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce temsirolimus and its active metabolite sirolimus concentrations, potentially lowering efficacy.
What this interaction means in plain words
Nevirapine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Temsirolimus belongs to Oncology.
Why it happens
Nevirapine induces CYP3A4, which metabolizes temsirolimus and sirolimus.
What to do
Consider an alternative antiretroviral; otherwise monitor response and consider a temsirolimus dose increase per labeling for inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Nevirapine with Temsirolimus?
MediHelp rates the interaction as moderate. Nevirapine and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce temsirolimus and its active metabolite sirolimus concentrations, potentially lowering efficacy.
How serious is the interaction between Nevirapine and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antiretroviral; otherwise monitor response and consider a temsirolimus dose increase per labeling for inducers.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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