Drug interactions
Nevirapine + Valbenazine
Severity: Major
Nevirapine and Valbenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can lower valbenazine and its active metabolite exposure. This may lead to loss of control of tardive dyskinesia or chorea.
What this interaction means in plain words
Nevirapine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nevirapine belongs to Anti Virals; Valbenazine belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP3A4, which metabolizes valbenazine to its active metabolite and clears the parent drug.
What to do
Avoid concomitant use as advised in valbenazine labeling for strong CYP3A4 inducers; consider a non-inducing antiretroviral. If coadministered, monitor movement symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Nevirapine with Valbenazine?
MediHelp rates the interaction as major. Nevirapine and Valbenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine can lower valbenazine and its active metabolite exposure. This may lead to loss of control of tardive dyskinesia or chorea.
How serious is the interaction between Nevirapine and Valbenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as advised in valbenazine labeling for strong CYP3A4 inducers; consider a non-inducing antiretroviral. If coadministered, monitor movement symptoms.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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