Drug interactions
Nevirapine + Vortioxetine
Severity: Moderate
Nevirapine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce vortioxetine exposure and weaken its antidepressant effect. Labeling suggests a dose increase when broad enzyme inducers are used for more than two weeks.
What this interaction means in plain words
Nevirapine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nevirapine belongs to Anti Virals; Vortioxetine belongs to Central Nervous System.
Why it happens
Nevirapine induces CYP enzymes, including CYP3A4 and CYP2B6, which contribute to vortioxetine clearance.
What to do
Monitor depressive symptoms and consider increasing the vortioxetine dose, not exceeding three times the original dose. Decrease the dose to baseline within 14 days of stopping nevirapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Nevirapine with Vortioxetine?
MediHelp rates the interaction as moderate. Nevirapine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce vortioxetine exposure and weaken its antidepressant effect. Labeling suggests a dose increase when broad enzyme inducers are used for more than two weeks.
How serious is the interaction between Nevirapine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor depressive symptoms and consider increasing the vortioxetine dose, not exceeding three times the original dose. Decrease the dose to baseline within 14 days of stopping nevirapine.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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