Drug interactions
Nicardipine + Silodosin
Severity: Moderate
Nicardipine and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a dihydropyridine calcium channel blocker that lowers blood pressure, and silodosin's alpha-1A blockade can add to this effect. Nicardipine also inhibits P-glycoprotein and CYP3A4, which may modestly raise silodosin exposure and further increase the risk of dizziness and orthostatic hypotension.
What this interaction means in plain words
Nicardipine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nicardipine belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilatory hypotension plus possible P-glycoprotein and CYP3A4 inhibition by nicardipine increasing silodosin exposure.
What to do
Monitor blood pressure and orthostatic symptoms when combining or adjusting doses. Reduce the dose of one agent if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Nicardipine
Frequently asked questions
Can I take Nicardipine with Silodosin?
MediHelp rates the interaction as moderate. Nicardipine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a dihydropyridine calcium channel blocker that lowers blood pressure, and silodosin's alpha-1A blockade can add to this effect. Nicardipine also inhibits P-glycoprotein and CYP3A4, which may modestly raise silodosin exposure and further increase the risk of dizziness and orthostatic hypotension.
How serious is the interaction between Nicardipine and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when combining or adjusting doses. Reduce the dose of one agent if hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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