Drug interactions
Nitisinone + Torsemide
Severity: Moderate
Nitisinone and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, the main enzyme that metabolizes torsemide, and may increase torsemide exposure. This could enhance diuresis and cause volume depletion or electrolyte disturbances.
What this interaction means in plain words
Nitisinone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nitisinone belongs to Miscellaneous; Torsemide belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9-mediated torsemide metabolism.
What to do
Monitor diuretic response, blood pressure, electrolytes and renal function. Reduce the torsemide dose if excessive diuresis occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Nitisinone with Torsemide?
MediHelp rates the interaction as moderate. Nitisinone and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitisinone inhibits CYP2C9, the main enzyme that metabolizes torsemide, and may increase torsemide exposure. This could enhance diuresis and cause volume depletion or electrolyte disturbances.
How serious is the interaction between Nitisinone and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, blood pressure, electrolytes and renal function. Reduce the torsemide dose if excessive diuresis occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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