Drug interactions
Nitisinone + Voriconazole
Severity: Minor
Nitisinone and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9 in vitro and could raise levels of CYP2C9 substrates. Voriconazole is only partly metabolized by CYP2C9, so any effect is likely small.
What this interaction means in plain words
Nitisinone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nitisinone belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Nitisinone may inhibit CYP2C9, a secondary pathway of voriconazole metabolism.
What to do
No routine adjustment is needed. Monitor for voriconazole adverse effects such as visual disturbance or hepatotoxicity, with trough levels if concerns arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Nitisinone with Voriconazole?
MediHelp rates the interaction as minor. Nitisinone and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9 in vitro and could raise levels of CYP2C9 substrates. Voriconazole is only partly metabolized by CYP2C9, so any effect is likely small.
How serious is the interaction between Nitisinone and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for voriconazole adverse effects such as visual disturbance or hepatotoxicity, with trough levels if concerns arise.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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