Drug interactions
Nizatidine + Vismodegib
Severity: Minor
Nizatidine and Vismodegib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Agents that raise gastric pH may lower the solubility of vismodegib and so reduce its absorption. The effect on antitumor efficacy has not been established. Clinical relevance is uncertain.
What this interaction means in plain words
Nizatidine and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nizatidine belongs to Gastrointestinal Tract; Vismodegib belongs to Oncology.
Why it happens
Increased gastric pH alters pH-dependent vismodegib solubility and may reduce its oral bioavailability.
What to do
No routine adjustment is required; monitor tumor response if acid suppression is long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Vismodegib
- Dexlansoprazole + Vismodegib Moderate
- Esomeprazole + Vismodegib Moderate
- Famotidine + Vismodegib Moderate
- Omeprazole + Vismodegib Moderate
- Pantoprazole + Vismodegib Moderate
- Aluminum hydroxide + Vismodegib Minor
Frequently asked questions
Can I take Nizatidine with Vismodegib?
MediHelp rates the interaction as minor. Nizatidine and Vismodegib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Agents that raise gastric pH may lower the solubility of vismodegib and so reduce its absorption. The effect on antitumor efficacy has not been established. Clinical relevance is uncertain.
How serious is the interaction between Nizatidine and Vismodegib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required; monitor tumor response if acid suppression is long term.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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