Drug interactions
Norethisterone + Tucatinib
Severity: Moderate
Norethisterone and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and may increase norethisterone exposure. The effect is likely modest, causing increased progestogenic adverse effects.
What this interaction means in plain words
Norethisterone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Norethisterone belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing norethisterone metabolism.
What to do
Monitor for progestogenic adverse effects such as bleeding changes, nausea or headache. Consider a nonhormonal contraceptive, since tucatinib can cause fetal harm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Norethisterone with Tucatinib?
MediHelp rates the interaction as moderate. Norethisterone and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and may increase norethisterone exposure. The effect is likely modest, causing increased progestogenic adverse effects.
How serious is the interaction between Norethisterone and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes, nausea or headache. Consider a nonhormonal contraceptive, since tucatinib can cause fetal harm.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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