Drug interactions
Ocrelizumab + Siltuximab
Severity: Moderate
Ocrelizumab and Siltuximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siltuximab neutralizes interleukin-6 and can mask fever and acute-phase responses to infection. With ocrelizumab, immune defense is further reduced and infections may be recognized late.
What this interaction means in plain words
Ocrelizumab and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ocrelizumab belongs to Central Nervous System; Siltuximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-6 neutralization and CD20 B-cell depletion.
What to do
Monitor closely for infection, keeping in mind that fever and CRP may be blunted. Treat suspected infection early.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Other interactions of Siltuximab
- Baricitinib + Siltuximab Major
- Atorvastatin + Siltuximab Moderate
- Carbamazepine + Siltuximab Moderate
- Cyclosporin + Siltuximab Moderate
- Ethinyl estradiol-drospirenone + Siltuximab Moderate
- Ethinyl estradiol-levonorgestrel + Siltuximab Moderate
Frequently asked questions
Can I take Ocrelizumab with Siltuximab?
MediHelp rates the interaction as moderate. Ocrelizumab and Siltuximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siltuximab neutralizes interleukin-6 and can mask fever and acute-phase responses to infection. With ocrelizumab, immune defense is further reduced and infections may be recognized late.
How serious is the interaction between Ocrelizumab and Siltuximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for infection, keeping in mind that fever and CRP may be blunted. Treat suspected infection early.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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