Drug interactions
Oliceridine + Rolapitant
Severity: Major
Oliceridine and Rolapitant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP2D6 and CYP3A4, and rolapitant's strong, prolonged CYP2D6 inhibition may raise its levels. This increases the risk of sedation and respiratory depression.
What this interaction means in plain words
Oliceridine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP2D6 by rolapitant reduces oliceridine clearance.
What to do
Monitor closely for sedation and respiratory depression and lengthen dosing intervals as needed. Reassess dosing if rolapitant effect wanes, since opioid effect may fall.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Rolapitant?
MediHelp rates the interaction as major. Oliceridine and Rolapitant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is metabolized by CYP2D6 and CYP3A4, and rolapitant's strong, prolonged CYP2D6 inhibition may raise its levels. This increases the risk of sedation and respiratory depression.
How serious is the interaction between Oliceridine and Rolapitant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for sedation and respiratory depression and lengthen dosing intervals as needed. Reassess dosing if rolapitant effect wanes, since opioid effect may fall.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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