Drug interactions
Omeprazole + Posaconazole
Severity: Moderate
Omeprazole and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole raises gastric pH, which lowers absorption of posaconazole oral suspension and may reduce antifungal efficacy. Delayed-release tablets are much less affected.
What this interaction means in plain words
Omeprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Higher gastric pH reduces dissolution and absorption of posaconazole suspension.
What to do
Prefer posaconazole delayed-release tablets or IV formulation, or avoid PPIs with the suspension. Monitor posaconazole levels if the suspension is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Omeprazole with Posaconazole?
MediHelp rates the interaction as moderate. Omeprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole raises gastric pH, which lowers absorption of posaconazole oral suspension and may reduce antifungal efficacy. Delayed-release tablets are much less affected.
How serious is the interaction between Omeprazole and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer posaconazole delayed-release tablets or IV formulation, or avoid PPIs with the suspension. Monitor posaconazole levels if the suspension is used.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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