Drug interactions
OnabotulinumtoxinA + Prochlorperazine
Severity: Minor
OnabotulinumtoxinA and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drugs with anticholinergic activity may add to the neuromuscular weakness produced by botulinum toxin. The clinical effect is generally modest but could cause excessive weakness or systemic anticholinergic symptoms.
What this interaction means in plain words
OnabotulinumtoxinA and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
OnabotulinumtoxinA belongs to Musculoskeletal; Prochlorperazine belongs to Central Nervous System.
Why it happens
Prochlorperazine has weak anticholinergic activity, which may add to the neuromuscular blockade of botulinum toxin; the evidence is largely theoretical.
What to do
No routine change is needed. Monitor for excessive weakness, swallowing or breathing difficulty after injection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for OnabotulinumtoxinA and Prochlorperazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of OnabotulinumtoxinA
Frequently asked questions
Can I take OnabotulinumtoxinA with Prochlorperazine?
MediHelp rates the interaction as minor. OnabotulinumtoxinA and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drugs with anticholinergic activity may add to the neuromuscular weakness produced by botulinum toxin. The clinical effect is generally modest but could cause excessive weakness or systemic anticholinergic symptoms.
How serious is the interaction between OnabotulinumtoxinA and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for excessive weakness, swallowing or breathing difficulty after injection.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
