Drug interactions
Ondansetron + Ozanimod
Severity: Moderate
Ondansetron and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod may slow heart rate and conduction, and ondansetron can prolong the QT interval. Together they may increase the risk of bradycardia and arrhythmia.
What this interaction means in plain words
Ondansetron and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on heart rate, conduction and QT interval.
What to do
Obtain an ECG before starting ozanimod in patients on ondansetron and monitor heart rate and ECG, especially with other cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ondansetron with Ozanimod?
MediHelp rates the interaction as moderate. Ondansetron and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod may slow heart rate and conduction, and ondansetron can prolong the QT interval. Together they may increase the risk of bradycardia and arrhythmia.
How serious is the interaction between Ondansetron and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod in patients on ondansetron and monitor heart rate and ECG, especially with other cardiac risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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