Drug interactions
Ondansetron + Panobinostat
Severity: Major
Ondansetron and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat markedly prolongs the QT interval and ondansetron adds to this effect, raising torsades de pointes risk. Labeling permits use of such antiemetics only with frequent ECG monitoring.
What this interaction means in plain words
Ondansetron and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ondansetron belongs to Gastrointestinal Tract; Panobinostat belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Prefer an antiemetic with less QT effect where possible. If ondansetron is used, perform frequent ECG monitoring and keep electrolytes normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Ondansetron with Panobinostat?
MediHelp rates the interaction as major. Ondansetron and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat markedly prolongs the QT interval and ondansetron adds to this effect, raising torsades de pointes risk. Labeling permits use of such antiemetics only with frequent ECG monitoring.
How serious is the interaction between Ondansetron and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic with less QT effect where possible. If ondansetron is used, perform frequent ECG monitoring and keep electrolytes normal.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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