Drug interactions
Ondansetron + Ranolazine
Severity: Moderate
Ondansetron and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine produces dose-related QT prolongation and ondansetron has a similar effect, so the two together may increase the risk of ventricular arrhythmia. Patients with heart disease, who often take ranolazine, are already at higher baseline risk.
What this interaction means in plain words
Ondansetron and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Ranolazine belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Correct electrolytes and limit ondansetron to the lowest effective dose. Obtain an ECG in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ondansetron with Ranolazine?
MediHelp rates the interaction as moderate. Ondansetron and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine produces dose-related QT prolongation and ondansetron has a similar effect, so the two together may increase the risk of ventricular arrhythmia. Patients with heart disease, who often take ranolazine, are already at higher baseline risk.
How serious is the interaction between Ondansetron and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct electrolytes and limit ondansetron to the lowest effective dose. Obtain an ECG in patients with additional risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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