Drug interactions
Ondansetron + Rizatriptan
Severity: Minor
Ondansetron and Rizatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been linked to serotonin syndrome in case reports when combined with other serotonergic agents. The practical risk with this pairing is low and they are often used together for migraine-related nausea.
What this interaction means in plain words
Ondansetron and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Rizatriptan belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic activity; mechanism is not well established.
What to do
Combined use is generally acceptable; advise patients to report agitation, tremor, sweating or fever. Stop the drugs if serotonin toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ondansetron and Rizatriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Ondansetron with Rizatriptan?
MediHelp rates the interaction as minor. Ondansetron and Rizatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have been linked to serotonin syndrome in case reports when combined with other serotonergic agents. The practical risk with this pairing is low and they are often used together for migraine-related nausea.
How serious is the interaction between Ondansetron and Rizatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Combined use is generally acceptable; advise patients to report agitation, tremor, sweating or fever. Stop the drugs if serotonin toxicity is suspected.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
