Drug interactions
Ondansetron + Rucaparib
Severity: Minor
Ondansetron and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 (and CYP1A2, 2C9, 2C19), and ondansetron is cleared by several CYP enzymes. Exposure to ondansetron may rise slightly, but because several pathways contribute, the effect is unlikely to be clinically significant.
What this interaction means in plain words
Ondansetron and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 and CYP1A2 by rucaparib, which modestly reduces ondansetron metabolism.
What to do
No dose change is normally needed. Be aware of additive QT effects and ECG monitoring if other risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Ondansetron with Rucaparib?
MediHelp rates the interaction as minor. Ondansetron and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 (and CYP1A2, 2C9, 2C19), and ondansetron is cleared by several CYP enzymes. Exposure to ondansetron may rise slightly, but because several pathways contribute, the effect is unlikely to be clinically significant.
How serious is the interaction between Ondansetron and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed. Be aware of additive QT effects and ECG monitoring if other risk factors are present.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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