Drug interactions
Ondansetron + Stiripentol
Severity: Minor
Ondansetron and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits and induces CYP3A4 and may inhibit P-glycoprotein, so ondansetron exposure could change in either direction. Ondansetron has multiple metabolic routes, so any effect is expected to be small.
What this interaction means in plain words
Ondansetron and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction, plus possible P-gp inhibition, by stiripentol may alter ondansetron clearance.
What to do
No empirical dose change is needed. Monitor antiemetic response and tolerability, especially at the start or end of stiripentol therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Ondansetron with Stiripentol?
MediHelp rates the interaction as minor. Ondansetron and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits and induces CYP3A4 and may inhibit P-glycoprotein, so ondansetron exposure could change in either direction. Ondansetron has multiple metabolic routes, so any effect is expected to be small.
How serious is the interaction between Ondansetron and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed. Monitor antiemetic response and tolerability, especially at the start or end of stiripentol therapy.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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