Drug interactions
Ondansetron + Tedizolid
Severity: Minor
Ondansetron and Tedizolid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron is a serotonergic agent and tedizolid is a weak reversible MAO inhibitor, so serotonin syndrome is theoretically possible. Clinical trials and labeling for tedizolid showed no serotonin toxicity signal, so the practical risk appears low.
What this interaction means in plain words
Ondansetron and Tedizolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Tedizolid belongs to Anti Bacterial.
Why it happens
Theoretical additive serotonergic effect from weak MAO inhibition combined with 5-HT3 antagonism, which is not well established as a true serotonergic mechanism.
What to do
Co-use is generally acceptable; watch for agitation, tremor, hyperthermia or clonus, and stop the serotonergic agent if these appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Ondansetron with Tedizolid?
MediHelp rates the interaction as minor. Ondansetron and Tedizolid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ondansetron is a serotonergic agent and tedizolid is a weak reversible MAO inhibitor, so serotonin syndrome is theoretically possible. Clinical trials and labeling for tedizolid showed no serotonin toxicity signal, so the practical risk appears low.
How serious is the interaction between Ondansetron and Tedizolid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-use is generally acceptable; watch for agitation, tremor, hyperthermia or clonus, and stop the serotonergic agent if these appear.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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