Drug interactions
Ondansetron + Triclabendazole
Severity: Moderate
Ondansetron and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval and ondansetron has a dose-related QT effect. Together they may raise the risk of torsades de pointes, particularly with other risk factors.
What this interaction means in plain words
Ondansetron and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ondansetron belongs to Gastrointestinal Tract; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid in patients with congenital long QT syndrome and correct electrolytes beforehand. Obtain an ECG if other QT risk factors exist or use an alternative antiemetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Ondansetron with Triclabendazole?
MediHelp rates the interaction as moderate. Ondansetron and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval and ondansetron has a dose-related QT effect. Together they may raise the risk of torsades de pointes, particularly with other risk factors.
How serious is the interaction between Ondansetron and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with congenital long QT syndrome and correct electrolytes beforehand. Obtain an ECG if other QT risk factors exist or use an alternative antiemetic.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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