Drug interactions
Ondansetron + Zileuton
Severity: Minor
Ondansetron and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton inhibits CYP1A2 and could slightly increase ondansetron exposure. Ondansetron's multiple metabolic pathways make a meaningful clinical effect unlikely.
What this interaction means in plain words
Ondansetron and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibits CYP1A2, a minor pathway for ondansetron metabolism.
What to do
No ondansetron dose adjustment is needed. Routine monitoring for adverse effects is sufficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Ondansetron with Zileuton?
MediHelp rates the interaction as minor. Ondansetron and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton inhibits CYP1A2 and could slightly increase ondansetron exposure. Ondansetron's multiple metabolic pathways make a meaningful clinical effect unlikely.
How serious is the interaction between Ondansetron and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No ondansetron dose adjustment is needed. Routine monitoring for adverse effects is sufficient.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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