Drug interactions
Osilodrostat + Propofol
Severity: Moderate
Osilodrostat and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and propofol has been associated with occasional QT prolongation and arrhythmia reports. Combined use during anesthesia may add to arrhythmia risk, especially with electrolyte disturbance.
What this interaction means in plain words
Osilodrostat and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Propofol belongs to Central Nervous System.
Why it happens
Possible additive prolongation of cardiac repolarization (QT interval).
What to do
Check ECG and correct potassium and magnesium before anesthesia, and monitor the ECG during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Propofol?
MediHelp rates the interaction as moderate. Osilodrostat and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and propofol has been associated with occasional QT prolongation and arrhythmia reports. Combined use during anesthesia may add to arrhythmia risk, especially with electrolyte disturbance.
How serious is the interaction between Osilodrostat and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before anesthesia, and monitor the ECG during and after the procedure.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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