Drug interactions
Osimertinib + Posaconazole
Severity: Moderate
Osimertinib and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib is partly metabolized by CYP3A4, and strong inhibitors such as posaconazole can modestly raise its exposure. This may increase toxicities such as QT prolongation, interstitial lung disease and diarrhea.
What this interaction means in plain words
Osimertinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated metabolism of osimertinib, increasing its plasma concentrations.
What to do
Prefer a non-azole antifungal when possible. If coadministered, monitor ECG and electrolytes and watch for pulmonary and gastrointestinal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Posaconazole?
MediHelp rates the interaction as moderate. Osimertinib and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib is partly metabolized by CYP3A4, and strong inhibitors such as posaconazole can modestly raise its exposure. This may increase toxicities such as QT prolongation, interstitial lung disease and diarrhea.
How serious is the interaction between Osimertinib and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-azole antifungal when possible. If coadministered, monitor ECG and electrolytes and watch for pulmonary and gastrointestinal toxicity.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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