Drug interactions
Ospemifene + Ticlopidine
Severity: Moderate
Ospemifene and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits CYP2C19, and ospemifene is partly metabolized by CYP2C19 along with CYP3A4 and CYP2C9. Ospemifene exposure may therefore increase, raising the risk of adverse effects such as hot flashes or thromboembolic events.
What this interaction means in plain words
Ospemifene and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ospemifene belongs to Endocrine; Ticlopidine belongs to Cardiovascular.
Why it happens
Ticlopidine inhibits CYP2C19-mediated metabolism of ospemifene.
What to do
Monitor for ospemifene adverse effects, particularly thromboembolic events and endometrial changes. Consider an alternative if clinically significant effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticlopidine
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Ospemifene with Ticlopidine?
MediHelp rates the interaction as moderate. Ospemifene and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits CYP2C19, and ospemifene is partly metabolized by CYP2C19 along with CYP3A4 and CYP2C9. Ospemifene exposure may therefore increase, raising the risk of adverse effects such as hot flashes or thromboembolic events.
How serious is the interaction between Ospemifene and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ospemifene adverse effects, particularly thromboembolic events and endometrial changes. Consider an alternative if clinically significant effects appear.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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