Drug interactions
Oxaliplatin + Pentamidine
Severity: Major
Oxaliplatin and Pentamidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic pentamidine is known to cause QT prolongation and torsades de pointes, and it can also cause electrolyte and glucose disturbances. Oxaliplatin may add to the arrhythmic risk.
What this interaction means in plain words
Oxaliplatin and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Use an alternative anti-infective if possible. If pentamidine is needed, monitor ECG and electrolytes and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Pentamidine?
MediHelp rates the interaction as major. Oxaliplatin and Pentamidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic pentamidine is known to cause QT prolongation and torsades de pointes, and it can also cause electrolyte and glucose disturbances. Oxaliplatin may add to the arrhythmic risk.
How serious is the interaction between Oxaliplatin and Pentamidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative anti-infective if possible. If pentamidine is needed, monitor ECG and electrolytes and correct potassium and magnesium.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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