Drug interactions
Oxycodone + Ozanimod
Severity: Moderate
Oxycodone and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and serotonergic or adrenergic drugs may theoretically cause hypertensive or serotonergic reactions. Oxycodone has weak serotonergic activity, so the risk is mainly theoretical.
What this interaction means in plain words
Oxycodone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Ozanimod belongs to Central Nervous System.
Why it happens
Possible weak MAO-B inhibition by an ozanimod metabolite combined with oxycodone's limited serotonergic activity.
What to do
Monitor blood pressure, heart rate, and signs of serotonin toxicity when combined. Consider another analgesic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Oxycodone with Ozanimod?
MediHelp rates the interaction as moderate. Oxycodone and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro, and serotonergic or adrenergic drugs may theoretically cause hypertensive or serotonergic reactions. Oxycodone has weak serotonergic activity, so the risk is mainly theoretical.
How serious is the interaction between Oxycodone and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, and signs of serotonin toxicity when combined. Consider another analgesic if symptoms develop.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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