Drug interactions
Oxycodone + Ranolazine
Severity: Minor
Oxycodone and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6 and may modestly raise oxycodone parent drug exposure while lowering oxymorphone formation. A clinically meaningful change is not expected in most patients.
What this interaction means in plain words
Oxycodone and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxycodone belongs to Musculoskeletal; Ranolazine belongs to Cardiovascular.
Why it happens
Weak CYP2D6 inhibition by ranolazine reduces oxycodone O-demethylation.
What to do
No routine dose change is needed. Monitor analgesic response and sedation when starting or stopping ranolazine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Oxycodone with Ranolazine?
MediHelp rates the interaction as minor. Oxycodone and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6 and may modestly raise oxycodone parent drug exposure while lowering oxymorphone formation. A clinically meaningful change is not expected in most patients.
How serious is the interaction between Oxycodone and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor analgesic response and sedation when starting or stopping ranolazine.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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