Drug interactions
Oxycodone + Rucaparib
Severity: Moderate
Oxycodone and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak-to-moderate CYP3A4 inhibitor and may raise oxycodone levels. This could increase sedation and respiratory depression.
What this interaction means in plain words
Oxycodone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 by rucaparib reduces oxycodone clearance.
What to do
Monitor for sedation and respiratory depression and reduce the oxycodone dose if signs of excess opioid effect appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Oxycodone with Rucaparib?
MediHelp rates the interaction as moderate. Oxycodone and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a weak-to-moderate CYP3A4 inhibitor and may raise oxycodone levels. This could increase sedation and respiratory depression.
How serious is the interaction between Oxycodone and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and reduce the oxycodone dose if signs of excess opioid effect appear.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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