Drug interactions
Oxycodone + Sevoflurane
Severity: Moderate
Oxycodone and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce the anesthetic requirement of volatile agents and add to respiratory depression and hypotension. This is expected in perioperative care but requires attentive dosing.
What this interaction means in plain words
Oxycodone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from opioid agonism and volatile anesthetic action.
What to do
Adjust anesthetic depth and opioid dosing together and monitor ventilation and hemodynamics. Observe closely for respiratory depression in recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Oxycodone with Sevoflurane?
MediHelp rates the interaction as moderate. Oxycodone and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids reduce the anesthetic requirement of volatile agents and add to respiratory depression and hypotension. This is expected in perioperative care but requires attentive dosing.
How serious is the interaction between Oxycodone and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust anesthetic depth and opioid dosing together and monitor ventilation and hemodynamics. Observe closely for respiratory depression in recovery.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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