Drug interactions
Oxycodone + Stiripentol
Severity: Moderate
Oxycodone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has mixed effects on CYP3A4 and can unpredictably change oxycodone exposure. It also causes somnolence, adding to opioid sedation.
What this interaction means in plain words
Oxycodone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition and induction by stiripentol plus additive CNS depression.
What to do
Start oxycodone at a low dose and titrate to effect, monitoring for both sedation or respiratory depression and inadequate analgesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Oxycodone with Stiripentol?
MediHelp rates the interaction as moderate. Oxycodone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has mixed effects on CYP3A4 and can unpredictably change oxycodone exposure. It also causes somnolence, adding to opioid sedation.
How serious is the interaction between Oxycodone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start oxycodone at a low dose and titrate to effect, monitoring for both sedation or respiratory depression and inadequate analgesia.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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