Drug interactions
oxycodone + tramadol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Concurrent use of two opioids increases risk of profound sedation, respiratory depression, hypotension, and overdose.
Mechanism of action
Additive pharmacodynamic CNS/respiratory depressant effects via mu-opioid receptor agonism.
Clinical management
Avoid dual opioid therapy when possible. If necessary, use the lowest effective doses for the shortest duration, avoid other CNS depressants, and closely monitor RR, SpO2, level of sedation, and BP; ensure naloxone availability.
Drug reference
References
- OxyContin (oxycodone hydrochloride) Prescribing Information — FDA Label
- Ultram (tramadol hydrochloride) Prescribing Information — FDA Label
Frequently asked questions
Can I take oxycodone with tramadol?
The interaction is rated: Major. Concurrent use of two opioids increases risk of profound sedation, respiratory depression, hypotension, and overdose.
How serious is the interaction between oxycodone and tramadol?
The interaction is rated: Major. Evidence level: High.
How is the interaction between oxycodone and tramadol managed?
Avoid dual opioid therapy when possible. If necessary, use the lowest effective doses for the shortest duration, avoid other CNS depressants, and closely monitor RR, SpO2, level of sedation, and BP; ensure naloxone availability.
Why do oxycodone and tramadol interact?
Additive pharmacodynamic CNS/respiratory depressant effects via mu-opioid receptor agonism.
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