Drug interactions
Oxycodone + Trimipramine
Severity: Moderate
Oxycodone and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is strongly sedating and anticholinergic, and with oxycodone can cause marked sedation, respiratory depression, constipation and urinary retention. Trimipramine is a CYP2D6 substrate and may also be affected by other interacting drugs.
What this interaction means in plain words
Oxycodone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Start with low doses and monitor sedation, bowel and bladder function, and respiratory status. Take extra care in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Oxycodone with Trimipramine?
MediHelp rates the interaction as moderate. Oxycodone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is strongly sedating and anticholinergic, and with oxycodone can cause marked sedation, respiratory depression, constipation and urinary retention. Trimipramine is a CYP2D6 substrate and may also be affected by other interacting drugs.
How serious is the interaction between Oxycodone and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor sedation, bowel and bladder function, and respiratory status. Take extra care in older adults.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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