Drug interactions
Ozanimod + Ranolazine
Severity: Moderate
Ozanimod and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and ranolazine prolongs the QT interval. Together they may add to arrhythmia risk, particularly bradycardia-related torsades.
What this interaction means in plain words
Ozanimod and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction and repolarisation, with ozanimod-induced bradycardia increasing the risk of QT-related arrhythmia.
What to do
Obtain an ECG before starting ozanimod. Seek cardiology advice before starting it in a patient on ranolazine, and monitor heart rate and QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Ranolazine?
MediHelp rates the interaction as moderate. Ozanimod and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and ranolazine prolongs the QT interval. Together they may add to arrhythmia risk, particularly bradycardia-related torsades.
How serious is the interaction between Ozanimod and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod. Seek cardiology advice before starting it in a patient on ranolazine, and monitor heart rate and QTc.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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