Drug interactions
Ozanimod + Risperidone
Severity: Moderate
Ozanimod and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can transiently slow heart rate and conduction, and risperidone can prolong the QT interval. Combined use may increase the risk of arrhythmia, so QT-prolonging drugs are generally not recommended at ozanimod initiation.
What this interaction means in plain words
Ozanimod and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive effects on heart rate, conduction and QT interval.
What to do
Obtain an ECG before starting ozanimod and seek cardiology input if the patient takes risperidone. Monitor heart rate and rhythm during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Risperidone?
MediHelp rates the interaction as moderate. Ozanimod and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can transiently slow heart rate and conduction, and risperidone can prolong the QT interval. Combined use may increase the risk of arrhythmia, so QT-prolonging drugs are generally not recommended at ozanimod initiation.
How serious is the interaction between Ozanimod and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology input if the patient takes risperidone. Monitor heart rate and rhythm during initiation.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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