Drug interactions
Ozanimod + Rizatriptan
Severity: Moderate
Ozanimod and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro. Rizatriptan is metabolized by MAO-A, but the labeling warns about hypertensive reactions and serotonergic effects with drugs affecting monoamines. The interaction is mostly theoretical.
What this interaction means in plain words
Ozanimod and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite adds to the monoaminergic and pressor effects of the triptan.
What to do
Monitor blood pressure and heart rate with concurrent use. Counsel the patient to report severe headache or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Rizatriptan?
MediHelp rates the interaction as moderate. Ozanimod and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B in vitro. Rizatriptan is metabolized by MAO-A, but the labeling warns about hypertensive reactions and serotonergic effects with drugs affecting monoamines. The interaction is mostly theoretical.
How serious is the interaction between Ozanimod and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate with concurrent use. Counsel the patient to report severe headache or palpitations.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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