Drug interactions
Ozanimod + Sevoflurane
Severity: Moderate
Ozanimod and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and its QT effect is small at usual doses. Sevoflurane can lengthen the QT interval and also cause bradycardia and hypotension. Together they may add to rhythm disturbances, though the risk is modest.
What this interaction means in plain words
Ozanimod and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization, including sphingosine-1-phosphate receptor mediated bradycardia.
What to do
Obtain a baseline ECG and review heart rate before anesthesia. Monitor heart rate and rhythm perioperatively and have anticholinergic treatment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sevoflurane?
MediHelp rates the interaction as moderate. Ozanimod and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and its QT effect is small at usual doses. Sevoflurane can lengthen the QT interval and also cause bradycardia and hypotension. Together they may add to rhythm disturbances, though the risk is modest.
How serious is the interaction between Ozanimod and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and review heart rate before anesthesia. Monitor heart rate and rhythm perioperatively and have anticholinergic treatment available.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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