Drug interactions
Ozanimod + Sotalol
Severity: Major
Ozanimod and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and AV conduction on initiation, which can add to the bradycardia and QT prolongation of sotalol. This increases the risk of torsades de pointes.
What this interaction means in plain words
Ozanimod and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive bradycardia and QT prolongation.
What to do
Avoid initiating ozanimod in patients on sotalol unless cardiology review judges the benefit to outweigh the risk; obtain a baseline ECG and monitor heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sotalol?
MediHelp rates the interaction as major. Ozanimod and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow heart rate and AV conduction on initiation, which can add to the bradycardia and QT prolongation of sotalol. This increases the risk of torsades de pointes.
How serious is the interaction between Ozanimod and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid initiating ozanimod in patients on sotalol unless cardiology review judges the benefit to outweigh the risk; obtain a baseline ECG and monitor heart rate.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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