Drug interactions
Ozanimod + Tramadol
Severity: Major
Ozanimod and Tramadol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolites of ozanimod inhibit MAO-B in vitro, and tramadol raises serotonin and norepinephrine. The combination could cause serotonin syndrome or hypertensive reactions. Labeling advises against combining ozanimod with drugs that raise these monoamines.
What this interaction means in plain words
Ozanimod and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
MAO inhibition by ozanimod metabolites combined with serotonin and norepinephrine reuptake inhibition by tramadol.
What to do
Avoid the combination and choose a non-serotonergic analgesic. If it cannot be avoided, monitor blood pressure and watch for signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Tramadol?
MediHelp rates the interaction as major. Ozanimod and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The active metabolites of ozanimod inhibit MAO-B in vitro, and tramadol raises serotonin and norepinephrine. The combination could cause serotonin syndrome or hypertensive reactions. Labeling advises against combining ozanimod with drugs that raise these monoamines.
How serious is the interaction between Ozanimod and Tramadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-serotonergic analgesic. If it cannot be avoided, monitor blood pressure and watch for signs of serotonin toxicity.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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