Drug interactions
Ozanimod + Trazodone
Severity: Major
Ozanimod and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and labeling advises against combining it with drugs that raise serotonin or norepinephrine. Combining it with trazodone raises concern for serotonin syndrome and blood pressure elevation. Clinical data are limited.
What this interaction means in plain words
Ozanimod and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites combined with serotonergic activity of trazodone, leading to additive serotonergic and adrenergic effects.
What to do
Avoid the combination where possible and consider alternatives. If used, monitor blood pressure and for serotonin toxicity such as agitation, tremor, hyperreflexia and hyperthermia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Trazodone?
MediHelp rates the interaction as major. Ozanimod and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolite inhibits MAO-B in vitro, and labeling advises against combining it with drugs that raise serotonin or norepinephrine. Combining it with trazodone raises concern for serotonin syndrome and blood pressure elevation. Clinical data are limited.
How serious is the interaction between Ozanimod and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider alternatives. If used, monitor blood pressure and for serotonin toxicity such as agitation, tremor, hyperreflexia and hyperthermia.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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